POS1109 GENETIC MARKERS PREDICT THE DEVELOPMENT OF POSTOPERATIVE PAIN

Background Postoperative pain (POP) is a serious complication that affects the outcome of total arthroplasty (TA) knee (CJ) and hip (HJ) joints in patients with osteoarthritis (OA). The search for genetic characteristics POP an urgent direction study this problem. Objectives To determine relationship between polymorphisms KCNS1, COMT, OPRM1 genes development postoperative joint who underwent arthroplasty. Methods group consisted 95 / or (64.6% women; mean age - 65.4 ± 9.0 years) TA CJ (47.8%) HJ (52.2 %). presence was determined when it persisted appeared after 3 6 months. After surgery, area operated ≥40 mm by 100 visual analogue scale. All genotyping KCNS1 (rs734784), COMT (rs6269, rs4633), (rs1799971) gene real-time polymerase chain reaction using original sequence-specific primers probes labeled various fluorescent labels. Registration interpretation obtained results were carried out on DT-96 amplifier (DNA-Technology LLC, Russia). Results observed 32.6% HJ. incidence 30.2% 34.0%, respectively (p = 0.882). There no differences frequencies genotypes studied (p>0.05). homozygous GG genotype polymorphism (rs734784) associated accordance recessive model (GG vs AA + AG; odds ratio (OR) 3.96 [95% confidence interval (CI): 1, 51; 10.37]; p 0.005). mutant allele T (TT CT) (rs4633) reduced risk developing compared carriage CC (OR 0.32 CI: 0.12; 0.83]; 0, 02) according to dominant model. statistically significant correlation alleles (rs6269) genes. Conclusion association chronic Further studies predisposition are required more clinical material. Disclosure Interests None declared